Postdoctoral Researcher in Biochemistry at CNRS – France

Summary

The National Centre for Scientific Research (CNRS) is offering a 36-month Postdoctoral Research Fellow position in Biochemistry, located in Gif-sur-Yvette, France, starting January 1, 2027. Based at the Institute for Integrative Biology of the Cell (I2BC) within the Biochemistry of Metalloproteins and Associated Diseases team, the researcher will investigate the biochemical mechanisms linking fatty acid synthesis and iron-sulfur (Fe-S) cluster biogenesis. Candidates must hold a PhD in a relevant scientific discipline with a strong background in biochemistry or biophysics. Responsibilities include protein purification, complex reconstitution under anaerobic conditions, enzymatic assays, and biophysical analyses. The gross monthly salary ranges between €3,131 and €4,526, alongside leave allowances and transport subsidies. Applications close on November 23, 2026.

Key Facts

Department	Biochemistry, Biophysics and Structural Biology (B3S)
Position Type	Postdoctoral Researcher
Discipline	Biochemistry
Research Area	Molecular and Structural Biology, Biochemistry
Degree Required	PhD in a relevant scientific discipline
Experience	Strong background in biochemistry and/or biophysics. Specific experience in protein purification is highly desirable. Knowledge or experience involving metalloproteins is appreciated. Experience with structural and spectroscopic methods is advantageous.
Salary	Gross monthly salary ranging from €3,131 to €4,526, depending on experience
Contract Duration	36 months
Deadline	2026-11-23
Employer Address	Gif-sur-Yvette, Essonne, France

About the Project

The project aims to elucidate the biochemical mechanisms connecting fatty acid synthesis and iron-sulfur (Fe-S) cluster biogenesis in prokaryotes through in vitro reconstitution of the prokaryotic ISC machinery alongside biochemical and biophysical investigations.

Key Responsibilities

• Purify proteins and reconstitute protein complexes under anaerobic conditions
• Prepare and analyse samples using biochemical, enzymatic, and biophysical techniques
• Investigate protein kinetics, protein-protein interactions, and structural modifications
• Conduct experiments using UV-visible spectroscopy and circular dichroism (CD)
• Apply isothermal titration calorimetry (ITC) and biolayer interferometry (BLI)
• Use FIDA technology, mass spectrometry, and NMR for sample analysis
• Contribute to the investigation of the molecular mechanisms connecting fatty acid synthesis with Fe-S cluster biogenesis

Required Skills

• PhD in a relevant scientific discipline
• Strong background in biochemistry and/or biophysics
• Experience in protein purification (desirable)
• Knowledge or experience involving metalloproteins (appreciated)
• Experience with structural and spectroscopic methods (advantageous)

Who Should Apply

Researchers holding a PhD in a relevant scientific discipline with a strong background in biochemistry or biophysics should apply. Experience in protein purification, metalloproteins, and structural or spectroscopic methods is advantageous. The position is also open to applicants holding a document recognizing their status as a disabled worker.

Benefits

• Gross monthly salary from €3,131 to €4,526, depending on experience
• 44 days of annual leave and RTT
• Remote-working arrangements and compensation
• Reimbursement of 75% of public transport costs
• Sustainable mobility allowance of up to €300

About the Employer

The Institute for Integrative Biology of the Cell (I2BC) is a research institute associated with CNRS, CEA, and Université Paris-Saclay, bringing together nearly 600 researchers on the CNRS campus in Gif-sur-Yvette, France.

Frequently Asked Questions

What is the contract duration for this postdoctoral position?

The position has a fixed-term contract duration of 36 months.

What is the application deadline?

The application deadline is November 23, 2026, at 11:59 PM.

Where is the research position located?

The position is located at the Institute for Integrative Biology of the Cell (I2BC) in Gif-sur-Yvette, Essonne, France.

What qualification is required to apply?

Applicants must hold a PhD in a relevant scientific discipline.

What is the salary range for this role?

The gross monthly salary ranges from €3,131 to €4,526, depending on experience.