Postdoctoral Researcher in Structural Virology at Karolinska Institutet, Sweden

Summary

Karolinska Institutet invites applications for a postdoctoral researcher in structural virology, based in the Department of Medicine, Solna, Sweden. The role focuses on elucidating viral entry, replication, and immune recognition through cryo‑electron microscopy, complemented by biochemical, biophysical, virological, and immunological approaches. The successful candidate will optimise samples, collect and process cryo‑EM data, build atomic models, and integrate findings with virology data. Responsibilities include project design, data interpretation, manuscript preparation, and conference presentations, with an expectation to develop independent research directions. Applicants must hold a PhD in a relevant field, possess documented cryo‑EM experience, and be proficient in protein expression, purification, and image‑processing tools. The position is a temporary full‑time contract with salary determined by KI’s collective agreements.

Key Facts

Key Responsibilities

• Optimize samples and prepare grids for cryo‑EM studies
• Collect cryo‑EM data at national facilities and process images
• Perform 3D reconstruction and build atomic models
• Integrate structural findings with virological and immunological data
• Contribute to project design, data interpretation, manuscripts, and conference presentations
• Develop independent research questions and a distinct research direction

Required Skills

• PhD in structural biology, biochemistry, biophysics, molecular biology or related field
• Documented cryo‑EM experience
• Recombinant protein expression and purification expertise
• Cryo‑EM sample preparation and grid optimisation
• Experience with image‑processing tools (e.g., RELION, cryoSPARC)
• Model‑building/refinement tools (e.g., Coot, Phenix, ChimeraX)
• Strong publication record
• Excellent English proficiency
• Ability to work independently and collaboratively

Who Should Apply

Candidates who have completed a PhD in structural biology, biochemistry, biophysics, molecular biology or a related discipline, and who have documented experience with cryo‑EM sample preparation, data collection, and image processing. Applicants should also be skilled in recombinant protein expression and purification, and be able to work both independently and collaboratively in an international research environment.

About the Employer

Karolinska Institutet (KI) is a leading Swedish research university. The position is located in the Department of Medicine, Solna, at the BioClinicum campus. KI offers a research environment focused on cutting‑edge structural virology and provides access to national cryo‑EM facilities.

Frequently Asked Questions

What is the application deadline?

20 October 2026

What type of contract is offered?

Temporary full‑time

Which documents must be submitted?

PhD certificate, complete CV, complete publication list, and a one‑page summary of current work